mechanism-of-action - EBC46 Research Hub

mechanism-of-action

EBC-46 Mechanism of Action: PKC-Delta, DAG Mimicry, and Vascular Disruption

How tigilanol tiglate activates PKC-delta through diacylglycerol mimicry, triggers vascular disruption, and produces localised tumour necrosis — a mechanistic overview.

mechanism-of-action

NF-κB Suppression and EBC-46: How PKC Activation Disrupts Tumour Survival Signalling

EBC-46's activation of protein kinase C does more than disrupt tumour vasculature — it may also suppress NF-κB, one of cancer's most critical survival signalling pathways.