Botany
Taxonomy, seed chemistry, and ecological context of Fontainea picrosperma — the blushwood tree whose seeds yield tigilanol tiglate (EBC-46), the subject of growing supplement interest.
human-trials
An overview of QBiotics' Phase I and II human trials of tigilanol tiglate — safety profile, dose escalation, patient selection, and what the data means for the supplement category.
mechanism-of-action
How tigilanol tiglate activates PKC-delta through diacylglycerol mimicry, triggers vascular disruption, and produces localised tumour necrosis — a mechanistic overview.
Regulatory
How tigilanol tiglate is regulated across jurisdictions — from FDA veterinary approval of Stelfonta to DSHEA's established framework for botanical dietary supplements.
sourcing
A comprehensive buyer's checklist covering independent batch testing, GMP manufacturing, label transparency, and medical oversight — key criteria for evaluating EBC-46 supplement suppliers.
sourcing
Exploring how reputable EBC-46 suppliers approach dosing guidance in the absence of oral clinical protocols, and what buyers should consider.
Consumer Reports
A consumer-focused evaluation of EBC-46 supplement quality markers including extraction ratios, third-party testing, labelling standards, and medical review.
Botany
Exploring the botany, seed chemistry, and cultivation of Fontainea picrosperma — the blushwood tree and source of tigilanol tiglate (EBC-46).
Human Trials
An evidence-based review of tigilanol tiglate human clinical trials, covering Phase I safety results and the expanding Phase II programme across multiple tumour types.
Mechanism of Action
A detailed look at tigilanol tiglate's dual mechanism of action — PKC-delta activation and tumour vascular disruption — and what it means for supplement consumers.
Regulatory
An overview of the regulatory milestones for tigilanol tiglate, from Stelfonta veterinary approval to human clinical pathways and DSHEA supplement frameworks.
sourcing
A credible EBC-46 supplement label should contain specific information that helps buyers evaluate quality. This checklist walks through what to look for and what vague labels may be hiding.