Marcus Webb

Mechanism of Action

Necroptosis and EBC-46: The RIPK1/RIPK3/MLKL Pathway in Tigilanol Tiglate Cell Death

Necroptosis is a regulated, lytic form of cell death distinct from apoptosis. We examine where tigilanol tiglate research intersects the RIPK1/RIPK3/MLKL axis.

Regulatory

UK MHRA Traditional Herbal Registration: How Botanical Supplements Like EBC-46 Fit the Framework

How the UK MHRA distinguishes Traditional Herbal Registrations from food supplements, and where blushwood berry extract products sit in that framework today.

Consumer Reports

Bottle Material and EBC-46 Tincture Stability: What Users Report About Glass vs. Plastic Storage

A summary of user reports on how bottle material — amber glass vs. plastic — affects perceived stability, taste and shelf life of EBC-46 blushwood berry tinctures.

Botany

Altitudinal Variation and EBC-46 Concentration in Fontainea picrosperma: How Elevation Shapes Blushwood Berry Chemistry

How elevation, temperature gradients and microclimate at different altitudes influence tigilanol tiglate concentration in Fontainea picrosperma seeds.

Human Trials

Phase III Pivotal Trial Design Considerations for Tigilanol Tiglate (EBC-46): What a Confirmatory Study Would Need

Methodological considerations that would shape a Phase III confirmatory trial for tigilanol tiglate, including endpoints, controls, and patient selection.

Mechanism of Action

TRAIL Receptor Pathway and EBC-46: Death Receptor Signalling in Tigilanol Tiglate-Induced Cell Death

How tigilanol tiglate, the active diterpene ester in EBC-46 research, intersects with the TRAIL/death receptor pathway and extrinsic apoptosis in tumour biology.

Regulatory

South Africa SAHPRA and EBC-46: How Complementary Medicines Regulations Apply to Blushwood Berry Supplements

How South Africa's SAHPRA regulates complementary medicines and where blushwood berry extract supplements like EBC-46 fit within the country's established framework.

Cycling On and Off Blushwood Berry Extract: What EBC-46 Supplement Users Report About Rest Periods

Many botanical-supplement users follow on/off cycling rather than continuous daily use. Here is what the user-report literature suggests for blushwood berry (EBC-46) extracts.

Seed Germination Physiology of Fontainea picrosperma: What Is Known About Blushwood Berry Propagation

A look at the seed biology and germination physiology of Fontainea picrosperma — the rainforest tree that produces the blushwood berry — and what botanical research has documented.

Inclusion and Exclusion Criteria in Tigilanol Tiglate Trials: How EBC-46 Patient Cohorts Are Defined

Inclusion and exclusion criteria are the gatekeepers of every clinical trial. Here is how they have been used to shape patient selection in tigilanol tiglate (EBC-46) studies.

Reactive Oxygen Species and EBC-46: How Oxidative Stress Fits Into the Tigilanol Tiglate Cell-Death Cascade

Reactive oxygen species generation is one of several stress signals associated with tigilanol tiglate (EBC-46) exposure. Here’s what the research literature describes.

Switzerland’s Botanical Supplement Framework and EBC-46: Swissmedic, FOPH, and the Food vs. Medicine Boundary

How Switzerland classifies blushwood berry (EBC-46) products under federal food-supplement and therapeutic-product law, and what this means for buyers comparing labels.