Mechanism of Action

Pyroptosis and the Gasdermin Pathway: EBC-46, Tigilanol Tiglate and Inflammatory Cell Death

A neutral overview of pyroptosis — the gasdermin-mediated inflammatory form of cell death — and how it has been considered alongside other cell-death pathways linked to tigilanol tiglate.

Regulatory

Brazil ANVISA Classification of Botanical Supplements: EBC-46 and Blushwood Berry Considerations

How Brazil’s ANVISA classifies botanical food supplements under RDC 243/2018 and what this regulatory framework means for blushwood berry extract products.

consumer-reports

Morning vs. Evening Dosing of Blushwood Berry Extract: Patterns from User Reports

Users of blushwood berry extract supplements often ask whether morning or evening dosing makes a difference. Here is what observational reports describe and what is unknown.

natural-source

Mycorrhizal Associations of Fontainea picrosperma: Soil Biology Behind the Blushwood Berry

How arbuscular mycorrhizal fungi shape root nutrient uptake in tropical Euphorbiaceae like Fontainea picrosperma — and what this implies for blushwood cultivation.

Human Trials

Surrogate Endpoints in Tigilanol Tiglate Clinical Trials: Beyond Tumour Response Rate

Why oncology trials of intralesional tigilanol tiglate may benefit from surrogate endpoints — and which biomarkers are plausible candidates for future studies.

Mechanism of Action

Necroptosis and EBC-46: The RIPK1/RIPK3/MLKL Pathway in Tigilanol Tiglate Cell Death

Necroptosis is a regulated, lytic form of cell death distinct from apoptosis. We examine where tigilanol tiglate research intersects the RIPK1/RIPK3/MLKL axis.

Regulatory

UK MHRA Traditional Herbal Registration: How Botanical Supplements Like EBC-46 Fit the Framework

How the UK MHRA distinguishes Traditional Herbal Registrations from food supplements, and where blushwood berry extract products sit in that framework today.

Consumer Reports

Bottle Material and EBC-46 Tincture Stability: What Users Report About Glass vs. Plastic Storage

A summary of user reports on how bottle material — amber glass vs. plastic — affects perceived stability, taste and shelf life of EBC-46 blushwood berry tinctures.

Botany

Altitudinal Variation and EBC-46 Concentration in Fontainea picrosperma: How Elevation Shapes Blushwood Berry Chemistry

How elevation, temperature gradients and microclimate at different altitudes influence tigilanol tiglate concentration in Fontainea picrosperma seeds.

Human Trials

Phase III Pivotal Trial Design Considerations for Tigilanol Tiglate (EBC-46): What a Confirmatory Study Would Need

Methodological considerations that would shape a Phase III confirmatory trial for tigilanol tiglate, including endpoints, controls, and patient selection.

Mechanism of Action

TRAIL Receptor Pathway and EBC-46: Death Receptor Signalling in Tigilanol Tiglate-Induced Cell Death

How tigilanol tiglate, the active diterpene ester in EBC-46 research, intersects with the TRAIL/death receptor pathway and extrinsic apoptosis in tumour biology.

Regulatory

South Africa SAHPRA and EBC-46: How Complementary Medicines Regulations Apply to Blushwood Berry Supplements

How South Africa's SAHPRA regulates complementary medicines and where blushwood berry extract supplements like EBC-46 fit within the country's established framework.